[{"data":1,"prerenderedAt":47},["ShallowReactive",2],{"q-nurse-106-1-basic-medicine-036":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":23},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"freq":11},"nurse-106-1-基礎醫學-036","nurse-106-1-basic-medicine-036",106,1,36,"下列何種腫瘤之發生最符合基因雙重打擊理論（two hit hypothesis）？",{"A":15,"B":16,"C":17,"D":18},"大腸癌（colon cancer）","視網膜芽細胞瘤（retinoblastoma）","乳癌（breast cancer）","肝癌（hepatocellular carcinoma）","B",null,[],"本題考點為抑癌基因的雙重打擊理論(two hit hypothesis)。依 Knudson 假說,抑癌基因需兩個對偶基因皆失活腫瘤才發生;視網膜芽細胞瘤(retinoblastoma)因 RB1 基因,遺傳型帶一個先天突變、再獲第二次體細胞突變即致病,最符合此模型,故正解為 B。大腸癌屬多步驟基因累積(APC、KRAS、p53 等),非單一雙擊模式,A 錯。乳癌與肝癌成因多元、涉及多基因與環境因子,並非雙重打擊的典型代表,C、D 錯。",[24,27,31,35,39,43],{"webId":25,"stem":26,"number":11,"year":10,"session":11},"nurse-106-1-basic-medicine-001","下列有關表皮的敘述，何者正確？",{"webId":28,"stem":29,"number":30,"year":10,"session":11},"nurse-106-1-basic-medicine-002","下列何者在組織學特徵上可區分為絲球帶（zona glomerulosa）、束狀帶（zona fasciculata）、網狀帶（zona reticularis）？",2,{"webId":32,"stem":33,"number":34,"year":10,"session":11},"nurse-106-1-basic-medicine-003","顴弓（zygomatic arch）是由顴骨與下列何者共同組成？",3,{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-106-1-basic-medicine-004","下列何者參與形成踝關節？",4,{"webId":40,"stem":41,"number":42,"year":10,"session":11},"nurse-106-1-basic-medicine-005","下列何者是維持背部直立最重要的肌肉？",5,{"webId":44,"stem":45,"number":46,"year":10,"session":11},"nurse-106-1-basic-medicine-006","行走於前臂的內側，並與上臂深層的靜脈會合成腋靜脈的是那一條血管？",6,1783840732144]