[{"data":1,"prerenderedAt":48},["ShallowReactive",2],{"q-nurse-108-2-basic-medicine-062":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":24},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"freq":23},"nurse-108-2-基礎醫學-062","nurse-108-2-basic-medicine-062",108,2,62,"leucovorin 與下列何種抗癌藥物同時使用，可以減低抗癌藥物的不良副作用？",{"A":15,"B":16,"C":17,"D":18},"azacitidine","5-Fluorouracil","methotrexate","6-Mercaptopurine","C",null,[],"本題考點為 leucovorin（folinic acid）的解救（rescue）機轉。methotrexate 屬抗葉酸劑，抑制二氫葉酸還原酶（DHFR），阻斷四氫葉酸生成而干擾 DNA 合成，對正常細胞亦有毒性。依 leucovorin 已是還原型葉酸、不需經 DHFR 即可供給正常細胞四氫葉酸，故高劑量 MTX 後給予 leucovorin 可選擇性挽救正常細胞、降低骨髓與黏膜毒性，選 C。（A）azacitidine 為去甲基化藥物，機轉與葉酸代謝無關。（B）5-Fluorouracil 與 leucovorin 併用反而增強其抑制胸苷酸合成酶之作用，是增效而非減毒。（D）6-Mercaptopurine 屬嘌呤類似物，毒性由 xanthine oxidase 代謝影響，非 leucovorin 解救對象。",1,[25,29,32,36,40,44],{"webId":26,"stem":27,"number":23,"year":28,"session":23},"nurse-106-1-basic-medicine-001","下列有關表皮的敘述，何者正確？",106,{"webId":30,"stem":31,"number":11,"year":28,"session":23},"nurse-106-1-basic-medicine-002","下列何者在組織學特徵上可區分為絲球帶（zona glomerulosa）、束狀帶（zona fasciculata）、網狀帶（zona reticularis）？",{"webId":33,"stem":34,"number":35,"year":28,"session":23},"nurse-106-1-basic-medicine-003","顴弓（zygomatic arch）是由顴骨與下列何者共同組成？",3,{"webId":37,"stem":38,"number":39,"year":28,"session":23},"nurse-106-1-basic-medicine-004","下列何者參與形成踝關節？",4,{"webId":41,"stem":42,"number":43,"year":28,"session":23},"nurse-106-1-basic-medicine-005","下列何者是維持背部直立最重要的肌肉？",5,{"webId":45,"stem":46,"number":47,"year":28,"session":23},"nurse-106-1-basic-medicine-006","行走於前臂的內側，並與上臂深層的靜脈會合成腋靜脈的是那一條血管？",6,1783840757670]