[{"data":1,"prerenderedAt":48},["ShallowReactive",2],{"q-nurse-110-2-basic-medicine-053":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":24},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"freq":23},"nurse-110-2-基礎醫學-053","nurse-110-2-basic-medicine-053",110,2,53,"免疫抑制劑 mycophenolate mofetil 用於腎臟移植時，可減少淋巴細胞異常增殖而緩解腎臟排斥作用，其作用機轉為何？",{"A":15,"B":16,"C":17,"D":18},"抑制 purine 的生合成","抑制 calcineurin 的活性","螯合 DNA 的作用","抑制轉錄因子 NFAT 的活性","A",null,[],"本題考點為免疫抑制劑 mycophenolate mofetil（MMF）的分子作用機轉。依其藥理，MMF 於體內水解為 mycophenolic acid，選擇性抑制 inosine monophosphate dehydrogenase（IMPDH），阻斷嘌呤（purine）的 de novo 合成路徑；淋巴細胞缺乏補救合成途徑而特別依賴此路徑，增殖因而被壓制、緩解移植排斥，故選 A。B 抑制 calcineurin 是 cyclosporine 與 tacrolimus 的機轉；D 抑制轉錄因子 NFAT 亦屬 calcineurin 訊息下游，兩者皆非 MMF 所為；C 螯合 DNA 並非其作用方式。",1,[25,29,32,36,40,44],{"webId":26,"stem":27,"number":23,"year":28,"session":23},"nurse-106-1-basic-medicine-001","下列有關表皮的敘述，何者正確？",106,{"webId":30,"stem":31,"number":11,"year":28,"session":23},"nurse-106-1-basic-medicine-002","下列何者在組織學特徵上可區分為絲球帶（zona glomerulosa）、束狀帶（zona fasciculata）、網狀帶（zona reticularis）？",{"webId":33,"stem":34,"number":35,"year":28,"session":23},"nurse-106-1-basic-medicine-003","顴弓（zygomatic arch）是由顴骨與下列何者共同組成？",3,{"webId":37,"stem":38,"number":39,"year":28,"session":23},"nurse-106-1-basic-medicine-004","下列何者參與形成踝關節？",4,{"webId":41,"stem":42,"number":43,"year":28,"session":23},"nurse-106-1-basic-medicine-005","下列何者是維持背部直立最重要的肌肉？",5,{"webId":45,"stem":46,"number":47,"year":28,"session":23},"nurse-106-1-basic-medicine-006","行走於前臂的內側，並與上臂深層的靜脈會合成腋靜脈的是那一條血管？",6,1783840764727]