[{"data":1,"prerenderedAt":48},["ShallowReactive",2],{"q-nurse-113-1-basic-medicine-037":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":23},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"freq":11},"nurse-113-1-基礎醫學-037","nurse-113-1-basic-medicine-037",113,1,37,"Milrinone具有強心及擴張血管之功能，長期使用會引發心律不整，此藥物的藥理作用機制為何？",{"A":15,"B":16,"C":17,"D":18},"第一型磷酸雙酯酶（phosphodiesterase 1）抑制劑","第二型磷酸雙酯酶（phosphodiesterase 2）抑制劑","第三型磷酸雙酯酶（phosphodiesterase 3）抑制劑","第五型磷酸雙酯酶（phosphodiesterase 5）抑制劑","C",null,[],"本題考點在於 milrinone 的藥理機轉。依藥理分類，milrinone 為第三型磷酸雙酯酶（PDE3）抑制劑，抑制心肌與血管平滑肌中分解 cAMP 的 PDE3，使 cAMP 累積：心肌增加鈣內流而正性收縮（強心）、血管平滑肌則鬆弛（擴張血管），故選 C。因細胞內鈣升高，長期使用易誘發心律不整。A、B、D 為第一、二、五型 PDE，作用組織與臨床用途不同（如 PDE5 抑制劑為 sildenafil），故錯。",[24,28,32,36,40,44],{"webId":25,"stem":26,"number":11,"year":27,"session":11},"nurse-106-1-basic-medicine-001","下列有關表皮的敘述，何者正確？",106,{"webId":29,"stem":30,"number":31,"year":27,"session":11},"nurse-106-1-basic-medicine-002","下列何者在組織學特徵上可區分為絲球帶（zona glomerulosa）、束狀帶（zona fasciculata）、網狀帶（zona reticularis）？",2,{"webId":33,"stem":34,"number":35,"year":27,"session":11},"nurse-106-1-basic-medicine-003","顴弓（zygomatic arch）是由顴骨與下列何者共同組成？",3,{"webId":37,"stem":38,"number":39,"year":27,"session":11},"nurse-106-1-basic-medicine-004","下列何者參與形成踝關節？",4,{"webId":41,"stem":42,"number":43,"year":27,"session":11},"nurse-106-1-basic-medicine-005","下列何者是維持背部直立最重要的肌肉？",5,{"webId":45,"stem":46,"number":47,"year":27,"session":11},"nurse-106-1-basic-medicine-006","行走於前臂的內側，並與上臂深層的靜脈會合成腋靜脈的是那一條血管？",6,1783840770926]